The Blues' young newcomers will get the chance to test themselves against a powerful Reds outfit.
While the Blues will take a 27-man squad featuring 18 uncapped players across the Tasman, they'll come up against a Reds side boasting 11 capped Wallabies from 2012.
Blues head coach John Kirwan said it would be a great challenge for his young team and he was looking forward to seeing them express themselves.
"They're all ready to go, they've been training really hard and now it's time to play," Kirwan said.
"We've left some of the more experienced guys at home, we know what they can do so it's a chance for the young boys to have a go."
Luke Braid will captain the side in the absence of Ali Williams, who alongside fellow All Blacks Piri Weepu and Charlie Faumuina, will not travel to Queensland.
Anthony Boric, Rene Ranger, Charles Piutau, Culum Retallick and George Moala will also remain at home.
The starting XV features nine players who have yet to pull on a Blues jersey including the entire backline, while nine reserves are also new to the franchise.
Blues: 15 Marty McKenzie, 14 Waisake Naholo, 13 Malakai Fekitoa, 12 Jackson Willison, 11 Frank Halai, 10 Baden Kerr, 9 Bryn Hall, 8 Peter Saili, 7 Luke Braid (captain), 6 Kane Barrett, 5 Ronald Raaymakers, 4 Liaki Moli, 3 Angus Ta'avao, 2 James Parsons, 1 Tom McCartney.
Replacements - from: Albert Nikoro, Lolagi Visinia, Pita Ahki, Francis Saili, Jamison Gibson-Park, Joe Edwards, Sean Polwart, Brendon O'Connor, Steven Luatua, Ofa Tu'ungafasi, Tim Perry, Quentin MacDonald.
Date: Saturday, February 2
Venue: Toowoomba Sports Ground, Toowoomba
Kick-off: 19.00 (09.00 GMT)
Referee: James Leckie (Australia)
Assistant referees: Rohan Hoffmann (Australia), Damien Mitchelmore (Australia)