Biarritz centre Marcelo Bosch and Montpellier full-back Lucas Gonzalez Amorosino will be new options for the back-line.
Coach Santiago Phelan has also added Biarritz prop Francisco Gomez Kodela and lock Nahuel Lobo of Stade Francais.
Prop Juan Gomez and centre Felipe Contepomi - whose international career could be over - are left out after picking up injuries during the 26-12 victory over Wales in Cardiff.
Contepomi, who had intended to retire from international rugby at the end of the autumn international series, was hurt in the first half at the Millennium Stadium
Racing Metro fly-half Juan Martin Hernandez picked up a slight injury in Cardiff but has been included in the squad to face the French, who crushed Australia 33-6 in Paris on Saturday night.
Argentina squad: Marcos Ayerza, Manuel Carizza, Agustin Creevy, Tomas De la Vega, Julio Farias Cabello, Juan Martin Fernandez Lobbe (captain), Juan Figallo, Francisco Gomez Kodela, Eusebio Guinazu, Juan Cruz Guillemain, Juan Manuel Leguizamon, Tomas Leonardi, Nahuel Lobo, Bruno Postiglioni, Leonardo Senatore, Tomas Vallejos, Horacio Agulla, Marcelo Bosch, Gonzalo Camacho, Lucas Gonzalez Amorosino, Santiago Cordero, Tomas Cubelli, Juan Martin Hernandez, Juan José Imhoff, Martin Landajo, Manuel Montero, Nicolas Sanchez, Gonzalo Tiesi, Joaquin Tuculet, Nicolas Vergallo
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The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
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