Five new forwards and three backs have been rushed into the line-up following the embarrassing 9-6 loss in Newcastle.
The all-Waratahs front-row of Sekope Kepu, Tatafu Polota-Nau and Benn Robinson will start the match at Suncorp Stadium, with second-rower Rob Simmons and number eight Wycliff Palu also returning to the starting XV.
Scott Higginbotham moves to blindside flanker to accommodate Palu's inclusion.
Deans has also re-shuffled his backline, including Adam Ashley-Cooper at full-back and partnering Rob Horne and Pat McCabe in the centres.
Brumbies half-back Nic White has been named on the bench and will become the 860th Wallaby if given a run.
Deans was always going to make changes regardless of the Scotland result, but it is clear a number of players played their way out of the team with poor performances.
Wales are the reigning Six Nations champions and will present much stiffer opposition than Scotland.
The Wallabies beat Wales 24-18 in Cardiff in December and have won eight of the nine Tests played in Australia.
The Welsh tasted their sole success on their inaugural visit in 1969, winning 19-16 in Sydney.
The Brisbane match is the first in a three-Test series.
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The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
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The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.