The 22-year-old has been cursed by injury in 2012 and will end the year on the sidelines after it was decided not to risk a persistent hamstring injury on the four-match end-of-season tour.
"[Just] had meeting with doc, looks like I'll be in £Teamrehab til after spring tour. Gutted I can't play but no risks with huge year ahead £2013," O'Connor wrote on his Twitter page.
The Australia Rugby Union also confirmed O'Connor absence on their official Twitter page in what is another blow to a team already heavily weakened by injury.
O'Connor has not played a Test this year because of liver and hamstring problems that also ruled him out of the majority of the Super 15 season for the Melbourne Rebels.
Australia have further injury doubts ahead of the tour, which begins against France in Paris on November 10, with skipper James Horwill (hamstring), David Pocock (knee) and Berrick Barnes (lung) all in some doubt of missing the trip.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.