Armitage features as one of three changes from last weekend's 67-3 victory over Romania, which was sparked by a quick-fire hat-trick from Cueto on his comeback from injury.
Matt Stevens starts at loosehead prop following an ankle injury and Courtney Lawes returns to the second row, having served a two-match ban.
An England victory will seal their passage to the World Cup quarter-finals as group winners - but defeat without any bonus points could bring their campaign to a crashing halt.
Alex Corbisiero and Tom Palmer drop to the bench but there is no place in the 22 for Cueto, with the more versatile Matt Banahan preferred among the replacements.
Number eight Nick Easter has replaced Tom Wood among the replacements after recovering from the back injury that kept him sidelined from the victories over Georgia and Romania.
Chris Ashton, whose five tries so far make him the tournament's leading try-scorer, Ben Foden, Manu Tuilagi, Dan Cole and James Haskell will all have started every England pool game.
Captain Lewis Moody will win his 70th cap on Saturday and Jonny Wilkinson his 90th.
England team to face Scotland: B Foden (Northampton Saints); C Ashton (Northampton Saints), M Tuilagi (Leicester Tigers), M Tindall (Gloucester Rugby), D Armitage (London Irish); J Wilkinson (Toulon), B Youngs (Leicester Tigers); M Stevens (Saracens), S Thompson (London Wasps), D Cole (Leicester Tigers), L Deacon (Leicester Tigers), C Lawes (Northampton Saints), T Croft (Leicester Tigers), L Moody (Bath Rugby, capt), J Haskell (Ricoh Black Rams).
Replacements: D Hartley (Northampton Saints), A Corbisiero (London Irish), T Palmer (Stade Francais), N Easter (Harlequins), R Wigglesworth (Saracens), T Flood (Leicester Tigers), M Banahan (Bath Rugby).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.