Saint-Andre's tenure got off to a successful start as Les Bleus beat Italy 30-12 in his first game in charge last weekend.
Despite that victory at the Stade de France, the former Sale supremo had hinted he would tinker with his starting XV and all four changes have come in the pack.
In the front-row Jean-Baptiste Poux takes over at loose-head prop from Vincent Debaty, while Dimitri Szarzewski is given the nod at hooker in place of William Servat.
Yoann Maestri of Toulouse has been preferred to veteran Lionel Nallet in the second row and will make his full debut after coming off the bench against Italy, while Imanol Harinordoquy takes over from Julian Bonnaire at flanker.
The back-line remains unchanged with Wesley Fofana retaining his place in the centres alongside Clermont team-mate Aurelien Rougerie following an impressive try-scoring debut last weekend and Francois Trinh-Duc continuing at fly-half.
France: Maxime Medard (Toulouse); Vincent Clerc (Toulouse), Aurelien Rougerie (Clermont), Wesley Fofana (Clermont), Julien Malzieu (Clermont); Francois Trinh-Duc (Montpellier), Dimitri Yachvili (Biarritz); Louis Picamoles (Toulouse), Imanol Harinordoquy (Biarritz), Thierry Dusautoir (Toulouse, capt); Yoann Maestri (Toulouse), Pascal Pape (Stade Français); Nicolas Mas (Perpignan), Dimitry Szarzewski (Stade Français), Jean Baptiste Poux (Toulouse).
Replacements: William Servat (Toulouse), Vincent Debaty (Clermont), Lionel Nallet (Racing-Metro), Julien Bonnaire (Clermont), Morgan Parra (Clermont), Lionel Beauxis (Toulouse), Maxime Mermoz (Perpignan).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.