Stade Francais scrum-half Dupuy and Toulouse fly-half Beauxis have got the nod ahead of the benched duo Morgan Parra and Francois Trinh-Duc for the encounter at the Stade de France.
Dupuy, who had a spell in England with Leicester, and Beauxis last played for France together in 2009, although they know each other well from their time at Stade.
"It's a strategic choice on my part," said Saint-Andre.
"England are the team that occupy the field of play the most, especially away from home.
"It's also because during our first three games we struggled to really get going, and we had trouble getting out of our own half during the first 20 minutes."
Prop David Attoub is once again the unlucky player to drop out of the initial 23-man squad named ahead of the clash.
Teams:
France: C Poitrenaud (Toulouse); V Clerc (Toulouse), A Rougerie (Clermont Auvergne), W Fofana (Clermont Auvergne), J Malzieu (Clermont Auvergne); L Beauxis (Toulouse), J Dupuy (Stade Francais); J-B Poux (Toulouse), D Szarzewski (Stade Francais), N Mas (Perpignan), P Pape (Stade Francais), Y Maestri (Toulouse), T Dusautoir (Toulouse, capt), J Bonnaire (Clermont Auvergne), I Harinordoquy (Biarritz).
Replacements: W Servat (Toulouse), V Debaty (Clermont Auvergne), L Nallet (Racing Metro), L Picamoles (Toulouse), M Parra (Clermont Auvergne), F Trinh-Duc (Montpellier), M Mermoz (Perpignan).
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