Stade Francais scrum-half Dupuy and Toulouse fly-half Beauxis have got the nod ahead of the benched duo Morgan Parra and Francois Trinh-Duc for the encounter at the Stade de France.
Dupuy, who had a spell in England with Leicester, and Beauxis last played for France together in 2009, although they know each other well from their time at Stade.
"It's a strategic choice on my part," said Saint-Andre.
"England are the team that occupy the field of play the most, especially away from home.
"It's also because during our first three games we struggled to really get going, and we had trouble getting out of our own half during the first 20 minutes."
Prop David Attoub is once again the unlucky player to drop out of the initial 23-man squad named ahead of the clash.
France: C Poitrenaud (Toulouse); V Clerc (Toulouse), A Rougerie (Clermont Auvergne), W Fofana (Clermont Auvergne), J Malzieu (Clermont Auvergne); L Beauxis (Toulouse), J Dupuy (Stade Francais); J-B Poux (Toulouse), D Szarzewski (Stade Francais), N Mas (Perpignan), P Pape (Stade Francais), Y Maestri (Toulouse), T Dusautoir (Toulouse, capt), J Bonnaire (Clermont Auvergne), I Harinordoquy (Biarritz).
Replacements: W Servat (Toulouse), V Debaty (Clermont Auvergne), L Nallet (Racing Metro), L Picamoles (Toulouse), M Parra (Clermont Auvergne), F Trinh-Duc (Montpellier), M Mermoz (Perpignan).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.