The 32-year-old will be making his first appearance of the summer after recovering from the neck/shoulder injury that forced him to sit out Ireland's defeats to Scotland and France in their previous World Cup warm-up matches.
He will line up at outside centre in what is virtually Ireland's strongest XV.
"It's great to be back. It's always difficult sitting out any Test matches. I'm looking forward to the weekend," O'Driscoll said.
Ireland: F Jones (Munster); A Trimble (Ulster), B O'Driscoll (Leinster, capt), G D'Arcy (Leinster), K Earls (Munster); J Sexton (Leinster), T O'Leary (Munster); C Healy (Leinster), R Best (Ulster), M Ross (Leinster), D O'Callaghan (Munster), P O'Connell (Munster), S O'Brien (Leinster), D Wallace (Munster), J Heaslip (Leinster).
Replacements: J Flannery (Munster), T Court (Ulster), M McCarthy (Connacht), S Ferris (Ulster), E Reddan (Leinster), R O'Gara (Munster), L Fitzgerald (Leinster).
France: Cedric Heymans (Toulouse); Maxime Medard (Toulouse), Aurelien Rougerie (Clermont), Fabrice Estebanez (Racing-Metro), Alexis Palisson (Brive); David Skrela (Toulouse), Morgan Parra (Clermont); Julien Bonnaire (Clermont), Louis Picamoles (Toulouse), Fulgence Ouedraogo (Montpellier); Lionel Nallet (Racing-Metro, capt), Pascal Pape (Stade Francais); Nicolas Mas (Perpignan), Dimitri Szarzewski (Stade Francais), Jean-Baptiste Poux (Toulouse).
Replacements: Guilhem Guirado (Perpignan), Fabien Barcella (Biarritz), Julien Pierre (Clermont), Raphael Lakafia (Biarritz), Dimitri Yachvili (Biarritz), Francois Trinh-Duc (Montpellier), Vincent Clerc (Toulouse), Luc Ducalcon (Castres).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
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Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
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The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
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The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
