Tobias Botes will play at fly-half, thus earning his first Azzurri start, with Kristopher Burton relegated to the bench alongside Gonzalo Canale, whose place at number 12 is taken by Alberto Sgarbi.
Benetton Treviso loosehead prop Michele Rizzo will make his Six Nations debut in Dublin, replacing veteran Andrea Lo Cicero, who drops to the bench.
Lorenzo Cittadini will make his first appearance in this year's tournament replacing injured Leicester prop Martin Castrogiovanni.
Castrogiovanni will miss the rest of the tournament after sustaining a fractured rib in the defeat by England.
Aironi prop Fabio Staibano has also been included in Brunel's 24-man squad for the first time since the summer of 2009.
Italy began their Six Nations campaign with a 30-12 loss at France and fell 19-15 to England in Rome in the last round.
Italy team to face Ireland at the Aviva Stadium on Saturday:
A Masi (Aironi Rugby); G Venditti (Aironi Rugby), T Benvenuti (Benetton Treviso), A Sgarbi (Benetton Treviso) , L McLean (Benetton Treviso); T Botes (Benetton Treviso), E Gori (Benetton Treviso); M Rizzo (Benetton Treviso), L Ghiraldini (Benetton Treviso), L Cittadini (Benetton Treviso), Q Geldenhuys (Aironi Rugby), M Bortolami (Aironi Rugby), A Zanni (Benetton Treviso), R Barbieri (Benetton Treviso), S Parisse (Stade Francais).
Replacements: T D'Apice (Aironi Rugby),F Staibano (Aironi Rugby), A Pavanello (Benetton Treviso), S Favaro (Aironi Rugby), F Semenzato (Benetton Treviso), K Burton (Benetton Treviso), G Canale (Clermont-Auvergne), A Lo Cicero (Racing-Metro Paris), G Toniolatti (Aironi Rugby).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.