South African-born Tobias Botes will make his first start for Italy against Ireland in the Six Nations in Dublin on Saturday - one of four changes to the Azzurri team.
He joins fellow South African Quintin Geldenhuys - who partners Marco Bortolami at lock - in the starting team, with another lock, SA-born Cornelius van Zyl, having been axed from the squad after the opening week of the tournament.
Another change sees Alberto Sgarbi - who was left out against England - coming back in at centre in place of Gonzalo Canale.
The other two changes are in the front row - where Michele Rizzo will make his first Six Nations appearance in place of the injured Martin Castrogiovanni.
Lorenzo Cittadini, making his first start in the tournament, is preferred to veteran Andrea Lo Cicero, who doesn't even make the bench with Fabio Staibano given that role instead.
Assistant coach Carlo Orlandi is confident the Italians will cope without the veteran prop, Castrogiovanni, who has been ruled out of the rest of the tournament.
He said: "The loss of Castrogiovanni is a big blow, because he is an experienced player who wants to win and an important member of the group. But we are confident [Lorenzo] Cittadini will play well, he doesn't carry the ball like Castro, but he's a very good player who is very strong in the scrum.
"The forwards will have to offer better ball to our three-quarters, we need to start playing a bit more, working on the aspects of the game which didn't work well against England. The Irish defence isn't hugely aggressive but it doesn't offer much space, playing through the phases will be key to finding the gaps to put them in trouble.”
Italy: 15 Andrea Masi, 14 Giovanbattista Venditti, 13 Tommaso Benvenuti, 12 Alberto Sgarbi, 11 Luke McLean, 10 Tobias Botes, 9 Edoardo Gori, 8 Sergio Parisse (captain), 7 Robert Barbieri, 6 Alessandro Zanni, 5 Marco Bortolami, 4 Quintin Geldenhuys, 3 Lorenzo Cittadini, 2 Leonardo Ghiraldini, 1 Michele Rizzo.
Replacements: 16 Tommaso D'Apice, 17 Fabio Staibano, 18 Antonio Pavanello, 19 Simone Favaro, 20 Fabio Semenzato, 21 Kris Burton, 22 Gonzalo Canale.
Date: Saturday, February 25
Venue: Aviva Stadium, Dublin
Kick-off: 13.30 (13.30 GMT)
Referee: Craig Joubert (South Africa)
Assistant referees: Nigel Owens (Wales), David Changleng (Scotland)
TMO: Nigel Whitehouse (Wales)
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.