Italy lost to Wales in Cardiff last weekend and will face Scotland in Rome on Saturday.
The Italians go into the encounter at the Stadio Olimpico on the back of a 24-3 loss in Cardiff and, like the Scots, will be determined to avoid the 'wooden spoon'.
Giovambattista Venditti replaces Luke McLean on the right wing while Tommaso Benvenuti will start at centre.
Benetton Treviso's Edoardo Gori replaces Fabio Semenzato at scrum-half while Simone Favaro drops to the bench with flanker Robert Barbieri taking his place in the starting XV.
Aironi lock Marco Bortolami replaces Cornelius Van Zyl to earn his 93rd cap.
Leicester Tigers prop Martin Castrogiovanni has recovered from a fractured rib that saw him miss the last two games and will start this weekend.
Australian-born lock Joshua Furno could make his Six Nations debut this weekend having been included in the squad. The 22-year-old made his Azzurri bow back in August.
Italy have won six of their 18 encounters against Scotland, who have not won in Rome since 2006.
Italy team to face Scotland: A Masi (Aironi Rugby); G Venditti (Aironi Rugby), T Benvenuti (Benetton Treviso), G Canale (Clermont-Auvergne),
Mirco Bergamasco (Racing-Metro Paris); K
Burton (Benetton Treviso), E Gori (Benetton Treviso); A Lo Cicero (Racing Metro-Paris), L Ghiraldini (Benetton Treviso), M Castrogiovanni (Leicester Tigers), Q Geldenhuys (Aironi Rugby), M Bortolami (Aironi Rugby), A Zanni (Benetton Treviso), R Barbieri (Benetton Treviso), S Parisse (Stade Francais).
Replacements: T D'Apice (Aironi Rugby), L Cittadini (Benetton Treviso), J Furno (Aironi Rugby), S Favaro (Aironi Rugby), M Vosawai (Benetton Treviso), T Botes (Benetton Treviso), G Toniolatti (Aironi Rugby), M Rizzo (Benetton Treviso), A Sgarbi (Benetton Treviso).
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