Italy will be without Martin Castrogiovanni for their Six Nations clash with Ireland after he failed to recover from a thigh injury.
The 31-year-old Leicester Tigers front-rower is replaced at tighthead by Treviso's Lorenzo Cittadini with Andrea Lo Cicero reclaiming the number one shirt from Alberto De Marchi.
There is also a change in the back row where Simone Favaro comes in for Robert Barbieri, who is out with a hip injury.
Jacques Brunel's side are looking for their first win over Ireland in the Six Nations and Favaro is determined to end the championship on a positive note.
"Against England we gained in confidence, we were able to put something in place," he said.
"But we must not forget we lost, even if the performance was satisfactory. Now we have a new battle, and new challenge, that we want to win, as we want to win every time we go onto the pitch.
"That is our spirit. Winning on Saturday is fundamental, we can't judge our tournament before the Ireland game. We can talk of the assessment of the tournament on Sunday."
Italy team: Masi, Venditti, Canale, Garcia, McLean, Orquera, Gori; Lo Cicero, Ghiraldini, Cittadini, Geldenhuys, Furno, Zanni, Favaro, Parisse.
Replacements: Giazzon, Rizzo, De Marchi, Pavanello, Minto, Derbyshire, Botes, Benvenuti.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.