Alastair Kellock returns to the starting line-up as captain for the EMC Test with the Azzurri at Murrayfield.
The match represents the final opportunity for head coach Andy Robinson to select his 30-man World Cup squad, which will be announced on Monday.
The head coach said: "We have made 14 changes from the team that started against Ireland as we want to give those players who have been working very hard in training the opportunity to put that into practice in Saturday's Test match against Italy.
"Historically Scotland have found Italy very tough opponents and it was no surprise to us that they achieved one of the results of the RBS 6 Nations Championship earlier this year when they accounted for France in Rome."
Scotland team: R Lamont (Toulon); M Evans (Castres), N De Luca (Edinburgh), G Morrison (Glasgow Warriors), S Danielli (Ulster); D Parks (Cardiff Blues), M Blair (Edinburgh); A Dickinson (Sale Sharks), S Lawson (Gloucester), M Low (Glasgow Warriors), N Hines (Clermont Ferrand), A Kellock (capt, Glasgow Warriors), K Brown (Saracens), R Vernon (Sale Sharks), J Barclay (Glasgow Warriors).
Replacements: D Hall (Glasgow Warriors), E Murray (Newcastle), R Gray (Glasgow Warriors), R Rennie (Edinburgh), C Cusiter (Glasgow Warriors), R Jackson (Glasgow Warriors), N Walker (Ospreys).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
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Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
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The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
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The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
