Rennie's stock rose in Scotland's disappointing RBS 6 Nations campaign, with the openside flanker among the nominees for player of the championship. Rennie, 26 tomorrow, now has 16 caps.
Both Rennie and centre De Luca, 28 and with 33 caps, are tied to the capital club until 2014.
Edinburgh head coach Michael Bradley said: "It's fantastic news for Edinburgh Rugby that players of the calibre of Ross and Nick have committed these crucial years of their rugby careers to the club."
Nineteen players have been retained by Bradley for next season, with the confirmation of deals for Rennie and De Luca a major boost ahead of the Heineken Cup quarter-final with Toulouse on Easter Saturday.
Rennie, whose international career stalled after his debut in 2008 due to a serious knee injury, said: "Having grown up in Edinburgh it means a lot to me to represent this club so I'm delighted to have extended my contract and to have secured the chance to play for the club I grew up supporting.
"Personally I'm in a good place just now. I'm happy with the way I'm playing for both the club and Scotland.
"I've made these developments as a player at this club and I'm confident that this is the right place for me to continue to improve.
"There's a lot of optimism about where we're going and I'm looking forward to being a part of that future."
De Luca added: "I'm really enjoying my rugby in Edinburgh. Our progress in the Heineken Cup has made this season a real landmark for even the most experienced players.
"Despite these highlights it's clear to all the players that we have opportunities to improve as individuals and as a team, combining a committed group of players who are signing on to something special with exciting new arrivals in the seasons ahead."
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