Former Wales captain Ryan Jones has joined prop Adam Jones and flanker Dan Lydiate in being ruled out of Saturday's Millennium Stadium clash through injury
But unlike his two colleagues, experienced back-row operator Jones is confidently expected to play a part in the four-match schedule and could return against Samoa on November 16.
The trio boast 177 caps between them, with Ryan Jones the obvious replacement for Lydiate, but Wales' number six shirt against Argentina now appears likely to be filled by Rob McCusker or his Scarlets colleague Aaron Shingler.
Wales also have the option of switching skipper Sam Warburton from openside to blindside flanker, which would mean a start for in-form Justin Tipuric, while Ospreys tighthead Aaron Jarvis remains on course for a Test debut as Adam Jones' deputy.
Ryan Jones flew home early from Wales' training camp in Poland last week to undergo scans on his shoulder, and he will now sit out the Pumas fixture.
"We were aware Ryan had a niggle with his shoulder coming out to Poland, so we thought it would be wise to get in there early and investigate if it was anything serious," forwards coach McBryde said.
"Happily enough that isn't the case, but it is a case of doing quite a bit of rehab work for the remainder of this week in order for him to be fit for next week's match against Samoa, which is positive news.
"It is well-chronicled on how valuable a player Ryan is, not only for Wales, but the Ospreys as well.
"Even though he is not involved in on-field training this week, he is around the players and sharing some of his experience."
Quizzed about the possibility of fielding Warburton and Tipuric in the same back-row, McBryde added: "When you have got two quality players at openside as we have in the squad, you can't discount it.
"Both Justin and Sam are hugely effective in their own different ways, and they could complement each other. It is definitely one we wouldn't throw out straightaway.
"Hopefully, our hand isn't forced, but should we have to go down that route then I am confident that we could be as effective and mould our game around that combination."
Argentina, fresh from a debut season in the southern hemisphere's Rugby Championship, are unlikely to pose many surprises for Wales.
Their strengths are traditionally based around the forwards, and McBryde sees no reason for that to change.
"It is something Argentina measure their game on - the scrum, the driving lineout, the driving maul," he said.
"I feel that is where they are going to come at us, and we have got to be able to stand up to that.
"It is important we start well and create that momentum, because if we show any chink in the armoury then teams are going to go after that a little bit more.
"I am confident that on Saturday we will more than stand up to Argentina."
The front-row selection will be among the more intriguing aspects of Wales' interim head coach Rob Howley's team selection tomorrow.
Toulon's Gethin Jenkins and Bath loosehead Paul James, who both missed the Poland trip due to club commitments, linked up with the Wales squad today.
Howley could start with Jenkins, whose first team opportunities at Toulon have been limited this season, and switch an in-form James to tighthead, or go for uncapped Jarvis ahead of fellow rookies Scott Andrews and Samson Lee.
"All three of them have more than held their own in the gym and with the amount of work we did on the training field (in Poland)," McBryde added.
"Gethin Jenkins and Paul James have joined us today to add that experience and help them along as well.
"We need to increase our strength in depth. And also because of the law changes at international level where you can now carry a full front-row (on the bench), you don't need a player who can cover both sides, so you need that specialist tighthead.
"Age shouldn't come into it, really, If you are good enough, you are old enough.
"The boys got through a tremendous amount of work in Poland. The boys who had been there before knew what they were in for, and they weren't disappointed.
"And it was great for the youngsters to step into that environment and be taken back somewhat as to what it was all about. Hopefully, we can transfer all that hard work into this week."
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