Both clubs are currently in the Premiership's mid-table zone after winning just 16 of 38 league games between them this season.
But a top-six finish - and prized Heineken Cup qualification next term - can still be achieved.
Sale are currently seventh, two points behind sixth-placed Gloucester and two in front of Bath, with Friday night's west country opponents currently occupying eighth spot.
Defeat for Bath in Stockport - their first fixture since it was announced that rugby director Sir Ian McGeechan and forwards coach Martin Haag will not be at the club beyond this season - would effectively end hopes of a top-half finish.
After Sale, Bath host struggling Wasps and then visit Leicester, while the Sharks head to Gloucester on Saturday week before hosting Premiership leaders Harlequins.
Sale were beaten narrowly by relegation favourities Newcastle last time out, with Bath suffering a 26-6 home defeat against title play-off contenders Northampton.
"We were competitive at Newcastle, but we didn't manage the game for the full 80 minutes," Sale chief executive Steve Diamond said.
"We have hopefully rectified that in training.
"Our side has trained well this week, and we are looking forward to the final Friday night Premiership fixture at Edgeley Park. We aim to continue to progress and produce a good, hard-working performance."
Sale will embark on a ground-share with rugby league club Salford City Reds next season, and for their penultimate home game in Stockport the Sharks show three changes.
Andrei Ostrikov starts in the second-row alongside Kearnan Myall, while hooker Joe Ward also features and James Gaskell switches from lock to flanker, packing down alongside back-row colleagues David Seymour and Andy Powell.
Flanker Carl Fearns will face his former club, meanwhile, with Matt Banahan and Olly Barkley teaming up in Bath's midfield, and young fly-half prospect Tom Heathcote also starting.
Victory for Sale would see them overhaul Gloucester, but it is likely to be shortlived, given that the Cherry and Whites host Newcastle on Saturday, when Wasps visit Quins, Northampton tackle Leicester, Saracens travel to London Irish and Worcester entertain Exeter.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.