Youngs will take over the hooking duties from Dylan Hartley, who has been sidelined with a knee injury which threatens to keep him out of England's entire QBE autumn international series.
Ugo Monye will make his England comeback on the left wing in place of the injured Ben Foden, while Charlie Sharples deputises for the suspended Chris Ashton on the right wing.
Alex Goode continues at full-back while Brad Barritt and Manu Tuilagi link up in a hard-hitting centre partnership, with Toby Flood and Danny Care the half-backs.
There are a total of five changes from the 14-14 draw with South Africa in the summer, with Chris Robshaw back to captain the side after missing that Test with a broken hand.
Tom Johnson continues at blindside flanker after making his Test debut on the summer tour, while Tom Wood returns to the England fold after 14 injury-plagued months with a place on the bench.
The uncapped pair of Saracens prop Mako Vunipola and Wasps lock Joe Launchbury are primed to make their Test debuts off the bench.
Flood is the most experienced player in the England side with 50 caps. The combined total of England's starting line-up is just 215.
England team for the QBE international against Fiji at Twickenham on Saturday November 10 (kick-off 2.30pm):
A Goode (Saracens); C Sharples (Gloucester), M Tuilagi (Leicester), B Barritt (Saracens), U Monye (Harlequins); T Flood (Leicester), D Care (Harlequins); J Marler (Harlequins), T Youngs (Leicester), D Cole (Leicester), T Palmer (Wasps), G Parling (Leicester), T Johnson (Exeter), C Robshaw (Harlequins, capt), T Waldrom (Leicester).
Replacements: D Paice (London Irish), D Wilson (Bath), M Vunipola (Saracens), J Launchbury (Wasps), T Wood (Northampton), B Youngs (Leicester), O Farrell (Saracens), M Brown (Harlequins).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.