The duo are available again after returning from World Cup duty, while United States international Hayden Smith is also selected in the second row.
In the backline, Rodd Penney gets a start on the wing while Joe Maddock switches to full-back.
Owen Farrell starts the game at fly-half with Charlie Hodgson and Alex Goode both named amongst the replacements.
They are joined on the bench by England prop Matt Stevens and back rower Matt Hankin, who will make his full Saracens debut should he be called into action.
Meanwhile, Exeter, who were the only side to defeat Sarries on home soil in the Aviva Premiership last season, have made three changes - all in their back division - for the trip to Watford.
Coach Rob Baxter has opted to give Australian Pat Phibbs and Mylse Dorrian their first starts for the Chiefs, the duo replacing Kevin Barrett and Jack Nowell respectively.
The other alteration from the line-up that started last week's victory over the Ospreys sees Josh Tatupu come in for Bryan Rennie in the centres.
On the bench, Samoan international Junior Poluleuligaga comes into the match-day squad for the first time this season following his exertions at the Rugby World Cup.
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