Quins lost their unbeaten start to the Aviva Premiership season on Tuesday when they were beaten 19-11 by Saracens at Twickenham.
And Camacho, who scored the winning try for Quins in last season's Amlin Challenge Cup final before joining the Chiefs, is expecting Conor O'Shea's men to arrive at Sandy Park determined to bounce back.
"Psychologically it can be interesting when you lose for the first time," Camacho told the club's official site. "It is a double-edged sword - you don't know how it will go.
"They will want revenge very quickly but if they are feeling negative after the game they may not come into the game the way they wanted.
"If they are okay with Tuesday's match and see where they can improve, they might bounce back up and double their efforts and double their skill level.
"We have got to be ready for a very hard game and a very physical game. They gain momentum in games through the battle up front and getting the back-row running hard and we have to be ready for that."
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