The Chiefs should encounter few problems against Cavalieri Prato, opponents they crushed 68-0 at Sandy Park two months ago.
And if Perpignan defeat Newport Gwent Dragons in France on Saturday, they will head to Devon next week with a quarter-final place available for the victors.
"Perpignan will be a big game, but if we get too far ahead of ourselves then that is when we are going to fall over," Exeter assistant coach Ali Hepher said.
"This weekend will be tough. Any Italian side at home is a different kettle of fish to when they travel away, so we have to be fully prepared and perform to our maximum."
Exeter show 12 changes from the side that won away against Aviva Premiership relegation favourites Newcastle last weekend, with only forward trio Hoani Tui, Aly Muldowney and James Phillips remaining in a team captained by fly-half Gareth Steenson.
"For sure, the club has moved on quite a lot these last couple of years," Hepher added.
"Two years ago, it was league fixtures week in, week out, but now we get that mix of say three weeks of Premiership action, two weeks' Amlin, two weeks' LV= Cup and then back into the Premiership again.
"That kind of makes things exciting for the guys and keeps the enthusiasm going within the squad."
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.