A youthful Chiefs side opened up their challenge with a six-try rout of London Welsh and head coach Rob Baxter has kept faith in the majority of the squad.
The only changes of personnel come in the front-row, with a debut for hooker Jack Yeandle and starts for Luke Cowan-Dickie and Hoani Tui.
Baxter has tweaked the back division by moving Nic Sestaret to centre, with Jack Nowell named on the wing and Myles Dorrian switching to full-back.
The Ospreys have made seven changes to their line-up for the trip to Sandy Park.
Five of the changes come in the pack with Owen Williams, Arthur Ellis, Joe Bearman, Sam Williams and Ian Gough handed starts.
In the backs Sam Davies, who starred off the bench against Gloucester, and Tom Habberfield team up at half-back - with Matthew Morgan and Rhys Webb dropped to the bench.
Exeter: 15 Myles Dorrian, 14 Jack Nowell, 13 Nic Sestaret, 12 Sam Hill, 11 Mark Foster, 10 Henry Slade, 9 Junior Poluleuligaga (capt), 1 Luke Cowan-Dickie, 2 Jack Yeandle, 3 Hoani Tui, 4 Damian Welch, 5 Will Carrick-Smith, 6 Justin Blanchet, 7 Joel Conlon, 8 Dave Ewers.
Replacements: 16 Neil Clark, 17 Ben Moon, 18 Alex Brown, 19 Aly Muldowney, 20 Sam Simmonds, 21 Rob Coote, 22 Josh Tatupu, 23 Ian Whitten.
Ospreys: 15 Ross Jones, 14 Tom Grabham, 13 Ben John, 12 Jonathan Spratt, 11 Will Price, 10 Sam Davies, 9 Tom Habberfield, 8 Morgan Allen, 7 Arthur Ellis, 6 Joe Bearman (c), 5 Sam Williams, 4 Ian Gough, 3 Owen Williams, 2 Matthew Dwyer, 1 Marc Thomas.
Replacements:16 Scott Otten, 17 Ryan Bevington, 18 Nicky Thomas, 19 Lloyd Peers, 20 James King, 21 Rhys Webb, 22 Matthew Morgan, 23 Tom Isaacs.
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