Sale winger Mark Cueto will look to become the Aviva Premiership's leading try-scorer after he was recalled for Friday's visit of Exeter.
Cueto is currently tied with former Sharks team-mate Steve Hanley on 75, however he has been included in the Sale team after missing the LV= Cup win over Wasps.
Cueto replaces Cameron Shepherd in the line-up, with Rob Miller slotting back into the No 15 jersey.
There is a further change to the pack, with club captain David Seymour fit to return to the back row.
Exeter have opted to make wholesale changes to their line-up for the return to league action.
In the backs there are recalls for Luke Arscott, Sireli Naqelevuki, Jason Shoemark and Gareth Steenson.
Only Ben White retained his place in the pack following the win over Northampton in the LV= Cup, with starts for Richard Baxter, James Scaysbrook, Dean Mumm, Tom Hayes, Hoani Tui, Neil Clark and Ben Moon.
There will also be a first Premiership start for Watisoni Votu after the Fijian impressed in the Anglo-Welsh competition.
Sale: 15 Rob Miller, 14 Charlie Amesbury, 13 Jonny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 James Gaskell, 7 David Seymour (capt), 6 Dan Braid, 5 Kearnan Myall, 4 Tom Holmes, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison. Replacements: 16 Marc Jones, 17 Alasdair Dickinson, 18 Tony Buckley, 19 Fraser McKenzie, 20 Richie Vernon, 21 Will Cliff, 22 Nick Macleod, 23 Will Addison.
Exeter: 15 Luke Arscott, 14 Watisoni Votu, 13 Sireli Naqelevuki, 12 Jason Shoemark, 11 Jack Nowell, 10 Gareth Steenson, 9 Will Chudley, 8 Richard Baxter, 7 James Scaysbrook, 6 Ben White, 5 Dean Mumm, 4 Tom Hayes (capt), 3 Hoani Tui, 2 Neil Clark, 1 Ben Moon. Replacements: 16 Jack Yeandle, 17 Carl Rimmer, 18 Alex Brown, 19 Aly Muldowney, 20 Kai Horstmann, 21 Haydn Thomas, 22 Ignacio Mieres, 23 Phil Dollman.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
