Sale winger Mark Cueto will look to become the Aviva Premiership's leading try-scorer after he was recalled for Friday's visit of Exeter.
Cueto is currently tied with former Sharks team-mate Steve Hanley on 75, however he has been included in the Sale team after missing the LV= Cup win over Wasps.
Cueto replaces Cameron Shepherd in the line-up, with Rob Miller slotting back into the No 15 jersey.
There is a further change to the pack, with club captain David Seymour fit to return to the back row.
Exeter have opted to make wholesale changes to their line-up for the return to league action.
In the backs there are recalls for Luke Arscott, Sireli Naqelevuki, Jason Shoemark and Gareth Steenson.
Only Ben White retained his place in the pack following the win over Northampton in the LV= Cup, with starts for Richard Baxter, James Scaysbrook, Dean Mumm, Tom Hayes, Hoani Tui, Neil Clark and Ben Moon.
There will also be a first Premiership start for Watisoni Votu after the Fijian impressed in the Anglo-Welsh competition.
Sale: 15 Rob Miller, 14 Charlie Amesbury, 13 Jonny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 James Gaskell, 7 David Seymour (capt), 6 Dan Braid, 5 Kearnan Myall, 4 Tom Holmes, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison. Replacements: 16 Marc Jones, 17 Alasdair Dickinson, 18 Tony Buckley, 19 Fraser McKenzie, 20 Richie Vernon, 21 Will Cliff, 22 Nick Macleod, 23 Will Addison.
Exeter: 15 Luke Arscott, 14 Watisoni Votu, 13 Sireli Naqelevuki, 12 Jason Shoemark, 11 Jack Nowell, 10 Gareth Steenson, 9 Will Chudley, 8 Richard Baxter, 7 James Scaysbrook, 6 Ben White, 5 Dean Mumm, 4 Tom Hayes (capt), 3 Hoani Tui, 2 Neil Clark, 1 Ben Moon. Replacements: 16 Jack Yeandle, 17 Carl Rimmer, 18 Alex Brown, 19 Aly Muldowney, 20 Kai Horstmann, 21 Haydn Thomas, 22 Ignacio Mieres, 23 Phil Dollman.
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