The sixth-placed Cherry and Whites have won just one of their last six games in all competitions, and their record in the North-East is also poor, having failed to beat the Falcons on their home turf since an LV= Cup tie back in 2007.
Last weekend's Kingsholm defeat by Leicester marked the first time the club had lost three consecutive home games for six years, and they have managed just one win on the road so far this term, against Exeter at the start of November.
But Redpath insists he has no problem with the home side starting favourites, despite the Falcons currently propping up the table.
"We have nothing to lose," he said. "We probably go in as underdogs but I am happy with that, if they are favourites because of their track record against us then great.
"We know exactly what they are and what the teams that beat us in the past were.
"We need to have the same mentality we went to Exeter with, and to be very physical with it.
"Newcastle away is a massive game for us. We can't rely on our home form at the moment, so we have to rely on some of our away results.
"We'd love to have a full bill of health but we're not far short of it and we'll go up there with all guns blazing."
Redpath has made five changes to his side from defeat to the Tigers, among them is the inclusion of Samoa centre Eliota Fuimaono-Sapolu, returning from his three-week ban for his latest indiscretions on Twitter.
He partners Mike Tindall, fresh from being reinstated in England's elite squad and having a fine slashed after appealing against the punishments handed down by the RFU following his infamous night out in Queenstown during the World Cup.
James Simpson-Daniel, Tom Voyce, Dave Lewis and Scott Lawson make up the remainder of the quintet restored to the starting XV, with Redpath looking for his side to start turning narrow defeats into victories.
He said: "We have been in positions to win three games and we haven't, in any game you lose there are always reasons but we have been upfront about it.
"We are competing but that's the toughest part, there have been three Premiership games where we have lost by three points or less, we need to turn the screw on the times when we are in winning positions and we cannot hide from the facts; if we are messing up we are messing up.
"Away from home you need to be clean and clinical and we have not been that often enough."
Falcons boss Alan Tait, meanwhile, has made seven changes of his own for the Friday night contest, including bringing Scotland prop Euan Murray and former Gloucester scrum-half Jordi Pasqualin into his side.
And former England Under-20 cap Pasqualin is eager to put one over on his old employers.
"Gloucester haven't won here for three seasons and we will be trying our best to make this the fourth," Pasqualin told the Newcastle website.
"They are a quality side with great capability but we can give them a good game and make the most of our home advantage.
"As players we have to stay focused and as a club, staff and supporters included we have got to stay positive."
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