The Sharks are currently in sixth, two points clear of their hosts with just two games remaining in the eason.
Steve Diamond has made three changes to the side that beat Bath last time out. Among the backs, Will Addison comes in for Johnny Leota at outside centre while Dwayne Peel is replaced at scrum-half by Cillian Willis.
In the forwards, flanker James Gaskell makes way for Mark Easter.
Diamond is well aware of the importance of the game and the effort that will be required to secure the win.
"Kingsholm is always a difficult place to visit. A win would be the 'icing on the cake' for everybody at our club, but we know we'll have to produce our best performance of the season," he said.
Gloucester have had a difficult week following the departure of boss Bryan Redpath and forwards coach Carl Hogg will take charge for Saturday's game.
Hogg has made three changes for the encounter, with one switch injury-enforced. Skipper Luke Narraway is sidelined with a tight hamstring which is obviously a blow, but Gloucester have a more than adequate replacement in the form of Scotland international Alasdair Strokosch.
In the midfield, Tim Molenaar comes in for Eliota Fuimaono-Sapolu while at scrum-half Dave Lewis replaces Nick Runciman.
Hogg is under no illusions as to how important the clash is for the club and is hopeful that his men can give the fans something to cheer about after a difficult period.
"There's a Heineken Cup place up for grabs and we've got to look forward as a group and recognize that this is our last opportunity together at home at Kingsholm to make a statement," he said.
"We've underperformed over the last few weeks, there's no question about that. But we have an opportunity on Saturday to salvage some pride and some dignity on Saturday and that's key for us.
"We respect Sale. They're a quality team with quality players. But Saturday is about this group of players and how we want to be remembered.
"We've let our supporters down over the past two or three weeks and we're looking to put that right."
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