Gloucester suffered an agonising late 33-27 defeat away at the Ospreys in their first game - and director of rugby Nigel Davies has reacted by recalling a trio of England hopefuls.
Freddie Burns, Ben Morgan and Billy Twelvetrees, who all trained with England this week, are included, while Fiji back-row Akapusi Qera also returns.
London Welsh suffered a heavy 42-15 loss to the Exeter Chiefs, with the Exiles leaking four tries in the final 16 minutes.
As a result, head coach Lyn Jones has made nine changes of personnel - as well as two positional switches - for the trip to Kingsholm.
Tom Voyce, Dan Caprice, Jamie Stephenson, Tom Bristow, Will Hafu, Paulica Ion, Adam Brown, Matt Corker and Adam Balding are all handed starts.
On the bench, Jones names on-loan Paul Spivey and the returning Ed Jackson.
Gloucester: 15 Rob Cook, 14 Shane Monahan, 13 Mike Tindall (c), 12 Billy Twelvetrees, 11 Steph Reynolds, 10 Freddie Burns, 9 Jimmy Cowan, 8 Ben Morgan, 7 Akapusi Qera, 6 Matt Cox, 5 Will James, 4 Tom Savage, 3 Rupert Harden, 2 Huia Edmonds, 1 Nick Wood.
Replacements: 16 Koree Britton, 17 Dan Murphy, 18 Dario Chistolini, 19 Peter Buxton, 20 Ross Moriarty, 21 Dave Lewis, 22 Tim Molenaar, 23 Drew Locke.
London Welsh: 15 Tom Voyce, 14 Dan Caprice, 13 Sonny Parker, 12 Seb Jewell, 11 Nick Scott, 10 Gordon Ross, 9 Jamie Stephenson, 1 Tom Bristow, 2 Will Hafu, 3 Paulica Ion, 4 Adam Brown, 5 Matt Corker, 6 Lee Beach, 7 Michael Hills, 8 Adam Balding.
Replacements: 16 James Tideswell, 17 Greg Bateman, 18 Arthur Joly, 19 Paul Spivey, 20 Ed Jackson, 21 Nick Runciman, 22 Alex Davies, 23 James Lewis.
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