Former Harlequins lock James Percival returns to face his old side as the Warriors look to add a second home win of the season to their opening-day success over Sale.
Dale Rasmussen is brought back into the centres after serving his one-match suspension, while Shaun Perry will take his place at scrum-half after being passed fit.
Partnering him at half-back will be Andy Goode, who needs only three more points to reach 1,500 in total in his Premiership career.
In the pack, Tevita Taumeopeau is promoted from the bench to pack down at prop and Neil Best makes a return at flanker.
Prop Ceri Jones could also play against his former club after he was named among the replacements.
Meanwhile, Harlequins will hope to maintain their unbeaten start to the campaign after naming an unchanged starting XV for the clash.
The only change comes on the bench, where Seb Stegmann returns to the squad after coming back from injury.
Quins have won all three of their opening games, including a 42-6 thrashing of Gloucester last time out, but their opponents have not lost at Sixways for 16 matches in total.
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