The 19-year-old played a key part in Tigers' semi-final victory over Saracens after being called up as replacement for ankle injury victim Toby Flood.
Flood has been named on the bench this weekend, which is a positive sign for England head coach Stuart Lancaster prior to next month's three-Test South Africa tour.
Leicester show a solitary change following the Saracens success, with fit-again flanker Julian Salvi returning to the back-row alongside Steve Mafi and Thomas Waldrom.
England internationals Ugo Monye and Danny Care have recovered from injuries to line up for Harlequins.
Both players missed the narrow semi-final victory over Northampton a fortnight ago when Quins booked their first Premiership final appearance at Twickenham.
Care will partner Nick Evans, this season's players' player of the year, at half-back, while Monye forges the back-three combination alongside Tom Williams and Mike Brown.
Leicester: G Murphy (capt); H Agulla, M Tuilagi, A Allen, A Tuilagi; G Ford, B Youngs; M Ayerza, G Chuter, D Cole, G Skivington, G Parling, S Mafi, J Salvi, T Waldrom.
Replacements: T Youngs, L Mulipola, M Castrogiovanni, G Kitchener, C Newby, S Harrison, T Flood, S Hamilton.
Harlequins: M Brown; T Williams, G Lowe, J Turner-Hall, U Monye; N Evans, D Care; J Marler, J Gray, J Johnston, O Kohn, G Robson, M Fa'asavalu, C Robshaw (capt), N Easter.
Replacements: R Buchanan, M Lambert, W Collier, T Vallejos, T Guest, K Dickson, R Clegg, M Hopper.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.