Among the backs, Seb Stegmann comes in for the injured Tom Williams and in the forwards, Tom Guest starts at blindside, with the dynamic Maurie Fa'asavalu covering from the bench.
With Ross Chisholm unavailable through injury for up to eight weeks, Sevens specialist Ollie Lindsay-Hague is among the replacements from where he will hope to make his first appearance as a senior squad member following promotion from the Academy this season.
For Saracens Rhys Gill gets his first start of the season while Schalk Brits, Petrus du Plessis, Ernst Joubert, Richard Wigglesworth, Chris Wyles, Joel Tomkins and captain Steve Borthwick also return to the line-up for the match against the reigning champions.
On the bench, John Smit comes into the matchday 23 while there are also first outings of the season for second-row George Kruis, flanker Andy Saull and wing David Strettle after the trio missed the start of the term through injury.
Harlequins: 15 Mike Brown, 14 Seb Stegmann, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw, 6 Tom Guest, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Maurie Fa'asavalu, 21 Karl Dickson, 22 Rory Clegg, 23 Ollie Lindsay-Hague.
Saracens: 15 Alex Goode, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 Chris Wyles, 10 Owen Farrell, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Will Fraser, 6 Kelly Brown, 5 Alistair Hargreaves, 4 Steve Borthwick (capt), 3 Petrus du Plessis, 2 Schalk Brits, 1 Rhys Gill.Replacements: 16 John Smit, 17 Mako Vunipola, 18 Matt Stevens, 19 George Kruis, 20 Andy Saull, 21 Ben Spencer, 22 Charlie Hodgson, 23 David Strettle.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.