Toulouse academy graduate Gael Fickou will make his European debut at inside centre for the four-time champions. Clement Poitrenaud returns to the full-back berth meaning Yoann Huget shifts to left wing.
Pumas lock Patricio Albacete returns from international duty in the Rugby Championship and comes in on the bench. Veteran French international centre Yannick Jauzion is on the bench but will undergo a fitness test on matchday.
For Leicester, Steve Mafi and Scott Hamilton are both included in the starting XV on their return from injury.
Flanker Mafi and full-back Hamilton both missed the Aviva Premiership wins over Exeter Chiefs and Sale Sharks, but have returned to fitness in time for the European opener in France this weekend.
Loosehead prop Marcos Ayerza is also included in the Tigers squad for the first time this season on his return from international duty with Argentina.
Vereniki Goneva makes his Heineken Cup debut on the wing as two-time European champions Tigers visit four-time winners Toulouse in Pool 2.
Toulouse: 15 Clement Poitrenaud, 14 Vincent Clerc, 13 Florian Fritz, 12 Gael Fickou, 11 Yoann Huget, 10 Luke McAlister, 9 Jean Marc Doussain, 8 Louis Picamoles, 7 Thierry Dusautoir, 6 Yannick Nyanga, 5 Yoann Maestri, 4 Romain Millo Chlusky, 3 Census Johnston, 2 Gary Botha, 1 Gurthro Steenkamp.
Replacements: 16 Christopher Tolofua, 17 Jean Batiste Poux, 18 Antoine Guillamon, 19 Patricio Albacete, 20 Jean Bouilhou, 21 Yannick Jauzion, 22 Luke Burgess, 23 Timoci Matanavou.
Leicester: 15 Scott Hamilton, 14 Niall Morris, 13 Manu Tuilagi, 12 Anthony Allen, 11 Vereniki Goneva, 10 Toby Flood, 9 Ben Youngs, 8 Jordan Crane, 7 Thomas Waldrom, 6 Steve Mafi, 5 Geoff Parling, 4 Graham Kitchener, 3 Dan Cole, 2 Tom Youngs, 1 Logovi'i Mulipola.
Replacements: 16 George Chuter, 17 Marcos Ayerza, 18 Martin Castrogiovanni, 19 Ed Slater, 20 Richard Thorpe, 21 Sam Harrison, 22 George Ford, 23 Matt Smith.
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