Paul Hodgson will lead the Exiles out to celebrate his 200th game for the Aviva Premiership club.
Tom Homer has been named on the wing for the crucial reverse fixture. Homer is one of three personnel changes from last Saturday's victory in Paris. Adrian Jarvis will start at fly-half alongside Darren Allinson and Jamie Gibson comes in at openside with Ofisa Treviranus moving to eight.
"It was fantastic to win away at Racing Metro last week. We proved that we can compete at the top level in Europe away from home," said London Irish head coach Toby Booth.
"We're still very much in this tournament and fighting for our place. It is important we capitalise on last week's game and make tomorrow count."
The teams:
London Irish team: 15 Delon Armitage, 14 Tom Homer, 13 Joe Ansbro, 12 Jonathan Spratt, 11 Adam Thompstone, 10 Adrian Jarvis, 9 Darren Allinson, 8 Ofisa Treviranus, 7 Jamie Gibson, 6 Declan Danaher, 5 Matthew Garvey, 4 Bryn Evans, 3 Paulica Ion, 2 David Paice, 1 Clarke Dermody.Replacements: 16 Brian Blaney, 17 Max Lahiff, 18 Faan Rautenbach, 19 Bob Casey, 20 Richard Thorpe, 21 Topsy Ojo, 22 Shontayne Hape, 23 Paul Hodgson.
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