Paul Hodgson will partner Adrian Jarvis at scrum-half at Murrayfield, while Alex Corbisiero, James Buckland and Leo Halavatau will start in the front row.
Bob Casey will captain the side in the second row alongside James Sandford with Matt Garvey moving to blindside flanker.
Despite being out of the running for the quarter-finals, London Irish head coach Toby Booth said his team would approach this match like any other.
"We play every game to win it and this weekend is no exception," said Booth.
"We will go up to Edinburgh this weekend to be competitive and look to come away with a result."
Centre John Houston has been promoted to Edinburgh's front-line for the decisive clash.
He starts in place of centre Nick De Luca who has failed to recover sufficiently from a head knock sustained in the club's 27-24 win over Racing Metro at the Stade du Manoir last weekend.
The former Hawick back will start at inside-centre, meaning Matt Scott moves to outside-centre and Jim Thompson takes Houston's vacated place on the bench.
The match will be Houston's 20th appearance in the competition.
Roddy Grant replaces Ross Rennie at openside flank in the clash which is crucial for the hosts who are still chasing a play-off berth.
Edinburgh last qualified for the competition's quarter-finals nine years ago and go into the last round of matches level on 17 points with Cardiff.
To secure their spot in the play-offs, Edinburgh must win with a bonus point and hope that Cardiff do not follow suit in their clash against Racing Metro.
Edinburgh: Paterson, Jones, Scott, Houston, Visser, Laidlaw, Blair, Jacobsen, Ford, Cross, Gilchrist, Cox, Denton, Grant, Talei.
Replacments: Walker, Traynor, Gilding, Lozada, McInally, Godman, Thompson, Brown.
London Irish: Armitage, Ojo, Spratt, Hape, Thompstone, Jarvis, Hodgson, Gray, Sisi, Garvey, Casey, Sandford, Halavatau, Buckland, Corbisiero.
Replacements: Blaney, Lahiff, Rautenbach, Kennedy, Evans, Joseph, Shingler, Samson.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.