The now traditional Christmas fixture at the home of English rugby is set to attract another sell-out crowd as Quins look to retain their advantage at the top of the table.
The Exiles, meanwhile, have won just one of their last nine games in all competitions, and languish 11th in the table with only Sale below them.
Quins, who are unchanged from their win over Northampton, will start as overwhelming favourites, but Kingston and company are not taking Irish lightly.
"We wont think that we will know and understand every week the key things we have to get right," he told the club website.
"We treat them the same as everyone we play, we don't judge or treat sides differently just because they have won or lost more games, we have to make sure we have everything we want in place.
"It's not about reflecting on how things are going for them or not going for them. They should have beaten us at the Madejski six weeks ago and they will know that. Expectation is a very dangerous thing."
Kingston says everyone at Quins is eagerly awaiting another outing in one of the domestic season's biggest occasions.
"We are also aware it is a fantastic occasion and it is really exciting and I would be lying if I said playing there at Christmas time is not a great occasion to be involved in, I am sure the atmosphere will be fantastic again," he said.
"We have had some great moments at Twickenham over the last few years and hopefully it will be a cracking occasion and lets hope the match lives up to it, it won't be for want of trying."
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