John Hart and Marco Wentzel return to the pack and in the backs Tom Varndell, Hugo Southwell, Chris Bell and Nic Berry are all back in the team but the most significant name is on the bench.
Dom Waldouck is named as a replacement as he returns from six months out with injury.
World Cup returnees Joe Simpson and Zak Taulafo are both named on the bench as Wasps try to bounce back from last week's one-point defeat to Worcester.
The Dragons will make history whatever the result with Hallam Amos becoming the youngest player to play for a Welsh region at the age of 17 years and 28 days.
However, his record will not last the match if Jack Dixon comes off the bench - he is just 16 years and 313 days old.
"We don't take these decisions lightly," said Robert Beale, Director of Rugby said. "Hallam has come through the age grades and trained with the senior squad throughout the summer."
Wasps: Southwell, Varndell, Daly, Bell, Mayor, Davis, Berry, Castex, Lindsay, McIntyre, Filipo, Wentzel, Harris, Everard, Hart Reps: Webber, Taulafo, Broster, Powell, Burton, Simpson, Robinson, Waldouck
Dragons: Amos, I Evans, A Hughes, Robling, Poole, S Jones, W Evans; Price, Buckley, Buck, A Jones, S Morgan, Groves, Waterss, Brown Reps: Parry, Gustafson, N Williams, I Jones, Ellis, Bedford, Dixon, M Jones
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