Freddie Burns, Rory Lawson and Henry Trinder replace Nick Runciman, Tim Taylor and Mike Tindall for the Cherry and Whites, while Jonny May replaces Charlie Sharples on the right wing following his late try against Connacht.
"We've lost our way a little bit. This week we've tried to get back to where we were earlier in the season," head coach Bryan Redpath said.
"We are trying to rebuild a bit. We've actually been playing reasonably well without winning."
Wasps fly-half Nick Robinson knows his side must run out at Kingsholm with all guns blazing if they are to secure a result against his former club.
"We will need a big performance to get a result as Gloucester are always a formidable side at home," he said.
"For us to go down there and get a win we are going to have to be on top of all aspects of our game."
Joe Burton replaces long-term injury victim John Hart in one of three changes made by Wasps, with flanker Matt Everard and prop Ben Broster back after knocks.
Kick-off is at 3pm.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.