American Paul Emerick - hugely impressive off the bench in last week's defeat at Northampton - and Billy Vunipola come in for the injured Dom Waldouck and Jonathan Poff as Wasps aim to pull away from Newcastle at the bottom of the table.
Vunipola's return at number eight sees Sam Jones shift to openside and on the bench there is a welcome return for fit-again Kiwi lock Ross Filipo.
Wasps have won just one of their last 11 Premiership matches since October and coach Dai Young admits his players are still smarting from their 39-10 defeat to Gloucester earlier in the season.
"Gloucester gave us a real hiding earlier in the season down at Kingsholm and that still hurts. They played excellent rugby that day and so we are well aware that on that kind of form they are a difficult side to beat," said Young.
Meanwhile, Gloucester boss Bryan Redpath makes five changes in the wake of last week's last-minute defeat to Exeter last week, which was a big blow in their bid for a Heineken Cup place.
A new midfield partnership sees Henry Trinder, recovered from a broken jaw, line up alongside Tim Molenaar with Mike Tindall and Eliota Fuimaono-Sapolu dropped, and Nick Runciman starts at scrum-half in place of Dave Lewis.
Tom Savage partners Jim Hamilton in the second row in preference to Alex Brown who has been unwell this week while Peter Buxton takes over from the injured Matt Cox on the blindside flank.
"Wasps have had a horrendous injury list and they've lost several players to retirement. But that means they have a lot of motivation and a point to prove," said Redpath.
"We have to get our mindset right. We have to carry ball, we have to work hard to get anything out of the game. It's going to be tough because it's a big game for both clubs."
Wasps: 15 Hugo Southwell (c), 14 Jack Wallace, 13 Elliot Daly, 12 Paul Emerick, 11 Richard Haughton, 10 Nick Robinson, 9 Nic Berry, 8 Billy Vunipola, 7 Sam Jones, 6 Joe Launchbury, 5 Richard Birkett, 4 James Cannon, 3 Ben Broster, 2 Tom Lindsay, 1 Tim Payne.
Replacements: 16 Vladislav Korshunov, 17 Sakaria Taulafo, 18 Simon McIntyre, 19 Ross Filipo, 20 Tinus Du Plessis, 21 Charlie Davies, 22 Ryan Davis, 23 Tom Prydie.
Gloucester: 15 Jonny May, 14 Charlie Sharples, 13 Henry Trinder, 12 Tim Molenaar, 11 James Simpson-Daniel, 10 Freddie Burns, 9 Nick Runciman, 8 Luke Narraway (c), 7 Akapusi Qera, 6 Peter Buxton, 5 Jim Hamilton, 4 Tom Savage, 3 Rupert Harden, 2 Scott Lawson, 1 Dan Murphy.
Replacements: 16 Darren Dawidiuk, 17 Yann Thomas, 18 Shaun Knight, 19 Alex Brown, 20 Alasdair Strokosch, 21 Dan Robson, 22 Ryan Mills, 23 Mike Tindall.
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