Wasps have already qualified for the last eight but will not be letting up as they try to secure a home quarter-final contest with a win in Wales.
Christian Wade comes back into the starting XV with Tom Varndell, who scored a hat-trick last time out against Mogliano, retained on the opposite wing.
Centre Elliot Daly, prop Zak Taulafo, lock Joe Launchbury and flanker Jonathan Poff all return to the side while the half-back partnership of Nick Robinson and Charlie Davies continues.
The Dragons are unable to qualify for the quarter-finals and have opted for a reshuffle in their pack, with only skipper Lewis Evans keeping his place following last week's defeat to Bayonne.
There are fewer changes among the backs, although Ashleigh Smith comes in for Andy Tuilagi in the centres and Dan Evans replaces Steffan Jones at fly-half.
Wasps: 15 Hugo Southwell (c), 14 Christian Wade, 13 Elliot Daly, 12 Andrea Masi, 11 Tom Varndell, 10 Nick Robinson, 9 Charlie Davies, 8 Billy Vunipola, 7 Jonathan Poff, 6 Sam Jones, 5 Marco Wentzel, 4 Joe Launchbury, 3 Phil Swainston, 2 Tom Lindsay, 1 Zak Taulafo
Replacements: 16 T Rhys Thomas, 17 Tim Payne, 18 Will Taylor, 19 James Cannon, 20 Matt Everard, 21 Joe Simpson, 22 Stephen Jones.
Dragons: 15 Tom Prydie, 14 Will Harries, 13 Adam Hughes, 12 Ashley Smith, 11 Mike Poole, 10 Dan Evans, 9 Jonathan Evans 8 Toby Faletau, 7 Nic Cudd, 6 Lewis Evans (c), 5 Rob Sidoli, 4 Andrew Coombs, 3 Dan Way, 2 Sam Parry, 1 Phil Price.
Replacements: 16 Hugh Gustafson, 17 Owen Evans, 18 Nathan Buck, 19 Ian Nimmo, 20 Ieuan Jones, 21 Wayne Evans, 22 Steffan Jones, 23 Jack Dixon.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
