Earlier this month, Croft made his return from a neck injury in the league win at Worcester and has been named in the Tigers starting line-up.
Boris Stankovich and Vereniki Goneva both return from injury and are included in the Tigers team.
Dan Bowden starts at fly-half with George Ford and Toby Flood on international duty, while Brett Deacon is named as captain. Matt Cornwell will start his first senior game at Welford Road since his return to the club last summer.
Academy products and England U20 squad members Tom Price and Harry Wells are in line for their club debuts, with Price named in the second row and Wells among the replacements.
Meanwhile, England U18 winger Tom Howe, an emerging star in the Wasps Academy set-up, is set to make his first professional appearance for the club having being handed a start out wide.
Recent arrivals Stuart Commins and Charlie Hayter make their debuts, at scrum-half and in the centres respectively.
While Wasps find themselves short at lock due to injuries and international call-ups, Oxford University's Will Rowlands makes his first start for the club in the second-row, with a great opportunity to impress.
Leicester: 15 Mathew Tait, 14 Scott Hamilton, 13 Andy Forsyth, 12 Matt Cornwell, 11 Vereniki Goneva, 10 Dan Bowden, 9 Sam Harrison, 8 Brett Deacon (capt), 7 Richard Thorpe, 6 Tom Croft, 5 Tom Price, 4 Rob Andrew, 3 Logovi'i Mulipola, 2 Rob Hawkins, 1 Boris Stankovich.
Replacements: 16 George Chuter, 17 Jonny Harris, 17 Fraser Balmain, 19 Harry Wells, 20 Michael Noone, 21 Micky Young, 22 Andy Symons, 23 Adam Thompstone.
Wasps: 15 Jack Wallace, 14 Tom Howe, 13 Chris Mayor, 12 Charlie Hayter, 11 Jonah Holmes, 10 Tommy Bell, 9 Stuart Commins, 8 Sam Jones (capt), 7 Matt Everard, 6 Tinus Du Plessis, 5 Will Rowlands, 4 James Cannon, 3 Will Taylor, 2 Nathan Morris, 1 Tim Payne.
Replacements: 16 T Rhys Thomas, 17 Simon McIntyre, 18 Harry Williams, 19 Dave Hughes, 20 James Harris, 21 Will Robinson, 22 Chris Bell, 23 Hugo Southwell.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.