Wasps cannot progress to the semi-finals of the LV= Cup - a 34-8 defeat to Leicester last Saturday ended a six-game winning run in all competitions.
Wasps do, however, have a perfect played 10 won 10 record at Adams Park this season.
Sale need a bonus-point win to guarantee their place in the last eight - less and they will need to outscore Leicester by at least one match point.
The Sharks have lost all eleven away games they have played in all competitions this season.
The two sides have never met in the Anglo-Welsh Cup before, whilst Wasps won 25-18 when the two met in the Premiership on December 23.
Wasps prop Will Taylor said: "We want to stay undefeated at home and this is what we will be aiming to do in the next game.
"It doesn't matter whether we are playing in the Aviva Premiership or the LV= Cup, that record is something we are proud of and we all want to keep it going for as long as possible.
"We are a really tight-knit group and we all want to keep pushing so we will take that into the Sale game."
Sale captain David Seymour: "The way the LV is set up it means if you progress in your group it's straight into the semis.
"That's where any player wants to play so it gives us a good chance to try and play some play-off rugby.
"It's a massive opportunity for the club, and it can give us the chance to build some real momentum going forward into the Premiership games next month."
Wasps: 15 Tommy Bell, 14 Jack Wallace, 13 Jonah Holmes, 12 Charlie Hayter, 11 Tom Varndell, 10 Stephen Jones, 9 Charlie Davies, 8 Sam Jones (c), 7 Matt Everard, 6 Tinus Du Plessis, 5 Marco Wentzel, 4 James Cannon, 3 Will Taylor, 2 Nathan Morris, 1 Zak Taulafo.
Replacements: 16 Tom Lindsay, 17 Simon McIntyre, 18 Harry Williams, 19 Will Rowlands, 20 Jonathan Poff, 21 Stuart Commins, 22 Will Robinson, 23 Chris Bell.
Sale: 15 Cameron Shepherd, 14 Rob Miller, 13 Jonny Leota, 12 Sammy Tuitupou Captain, 11 Charlie Amesbury, 10 Danny Cipriani, 9 Dwayne Peel, 8 James Gaskell, 7 Dan Braid, 6 James Doyle, 5 Kearnan Myall, 4 Tom Holmes, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Marc Jones, 17 Aston Croall, 18 Tony Buckley, 19 Tom Cruse, 20 Billy Emerson, 21 Will Cliff, 22 Jordan Davies, 23 Charlie Ingall.
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