Ernst Joubert comes in at No 8 to skipper the side as club captain Steve Borthwick is rested and his place in the second row taken by George Kruis, who switches from flanker.
Schalk Brits drops to the bench after the win against Bath last time out, with his place at hooker taken by fellow South African star John Smit.
Richard Wigglesworth and Owen Farrell also have to settle for spots on the bench as their respective places at scrum-half and inside centre are taken by Neil de Kock and Brad Barritt.
Andy Saull, Alex Goode, Jackson Wray, Alistair Hargreaves, Joe Maddock, Adam Powell, Jacques Burger and Justin Melck all miss the match through injury
Northampton also make four changes to their line-up following their 18-9 defeat to league leaders Harlequins, although three of those are made in the process of overhauling the front row.
Captain Dylan Hartley comes back in at hooker after serving a suspension and is joined by props Brian Mujati and Alex Waller. The remaining change sees Tom May replaced by Dom Waldouck at inside centre.
Sarries currently lie one point behind Quins at the Aviva Premiership summit while Northampton are two points outside the top four.
Saracens: 15 Chris Wyles, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 David Strettle, 10 Charlie Hodgson, 9 Neil de Kock, 8 Ernst Joubert (c), 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 George Kruis, 3 Matt Stevens, 2 John Smit, 1 Mako Vunipola.
Replacements: 16 Schalk Brits, 17 Rhys Gill, 18 Carlos Nieto, 19 Eoin Sheriff, 20 Jono Ross, 21 Richard Wigglesworth, 22 Owen Farrell, 23 James Short.
Northampton: 15 Ben Foden, 14 Ken Pisi, 13 George Pisi, 12 Dom Waldouck, 11 Jamie Elliott, 10 Stephen Myler, 9 Lee Dickson, 8 GJ Van Velze, 7 Phil Dowson, 6 Tom Wood, 5 Courtney Lawes, 4 Samu Manoa, 3 Brian Mujati, 2 Dylan Hartley (c), 1 Alex Waller.
Replacements: 16 Mike Haywood, 17 Soane Tonga'uiha, 18 Paul Doran Jones, 19 Mark Sorenson, 20 Calum Clark, 21 Martin Roberts, 22 Ryan Lamb, 23 Tom May.
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