Saints must win with a bonus point at Scotstoun and then hope that elsewhere various results go their way.
The visitors have named an unchanged starting XV. The only change to the matchday 23 is GJ Van Velze's addition to the bench.
Meanwhile, it is a different story for Glasgow, with coach Gregor Townsend having made ten changes to his starting team.
There are only five players who remain in the starting line-up. James Eddie switches from open to blindside, Josh Strauss moves from number eight to openside, Sean Maitland moves from right to left wing and Moray Low and Al Kellock remain in their positions of lock and tighthead respectively.
Ruaridh Jackson and Niko Matawalu replace Duncan Weir and Henry Pyrgos at fly-half and scrum-half respectively, as Scott Wight remains on the bench as cover for Jackson. Sean Kennedy comes in on the bench as Pyrgos drops out the squad.
Ryan Wilson is at eight and Tom Ryder moves to the bench as he makes way for Tim Swinson.
Pat MacArthur and Gordon Reid replace Doug Hall and Ryan Grant at hooker and loosehead prop respectively. Hall and Grant remain on the bench with the number 18 jersey unfulfilled for a second week.
Glasgow: 15 Stuart Hogg, 14 Tommy Seymour, 13 Byron McGuigan, 12 Graeme Morrison, 11 Sean Maitland, 10 Ruaridh Jackson, 9 Niko Matawalu, 8 Ryan Wilson, 7 James Eddie, 6 Josh Strauss, 5 Al Kellock (capt), 4 Tim Swinson, 3 Moray Low, 2 Pat MacArthur, 1 Gordon Reid.
Replacements: 16 Doug Hall, 17 Ryan Grant, 18 N/A, 19 Tom Ryder, 20 Alex Dunbar, 21 Sean Kennedy, 22 Scott Wight, 23 Peter Horne.
Northampton: 15 Ben Foden, 14 James Wilson, 13 George Pisi, 12 Dom Waldouck, 11 Jamie Elliott, 10 Steve Myler, 9 Lee Dickson, 8 Phil Dowson, 7 Tom Wood, 6 Calum Clark, 5 Courtney Lawes, 4 Samu Manoa, 3 Paul Doran-Jones, 2 Dylan Hartley, 1 Soane Tonga'uiha.
Replacements: 16 Mikey Haywood, 17 Alex Waller, 18 Tom Mercey, 19 Mark Sorenson, 20 Rhys Oakley, 21 Martin Roberts, 22 Ryan Lamb, 23 Tom May.
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