Deon Carstens is preferred at prop to the benched Rhys Gill, while Chris Wyles make his first start since returning from the World Cup.
James Short makes way for the American, with the winger joined among the replacements by Adam Powell.
Wales international Andy Powell comes into the Sale line-up for the trip to the capital.
Executive director of sport Steve Diamond has also made further changes on the bench, with Cillian Willis, who has joined the club from Leinster for the rest of the season, providing cover at scrum-half after Dwayne Peel and Scott Mathie were both sidelined.
Samoa fly-half Tasesa Lavea is also named among the replacements and will make his debut if called upon after finally arriving at the club following the World Cup.
And Diamond is keen to do well against his former club.
"It's a long time ago since I left Saracens. They have created a super franchise. They are now going away from home and winning at Gloucester ,so we know that we are up against a top side on Sunday," he said.
"In the end it's all about our performance this weekend. If we get it right in our set piece and defence then we stand a chance of getting something out of the game.
"They are one of the top super clubs in England right now and if you get anything from them away from home, then you are doing well," added Diamond.
Saracens: 15 Alex Goode, 14 David Strettle, 13 Owen Farrell, 12 Brad Barritt, 11 Chris Wyles, 10 Charlie Hodgson, 9 Neil de Kock, 1 Deon Carstens, 2 Schalk Brits, 3 Carlos Nieto, 4 Steve Borthwick (c), 5 Mouritz Botha, 6 Kelly Brown, 7 Jacques Burger, 8 Ernst Joubert.Replacements: 16 Jamie George, 17 Rhys Gill, 18 Matt Stevens, 19 Hayden Smith, 20 Andy Saull, 21 Ben Spencer, 22 Adam Powell, 23 James Short
Sale: 15 Rob Miller, 14 Will Addison, 13 Johnny Leota, 12 Sam Tuitupou (capt), 11 Mark Cueto, 10 Nick Macleod, 9 Will Cliff, 1 Alasdair Dickinson, 2 Tommy Taylor, 3 Henry Thomas, 4 Fraser McKenzie, 5 James Gaskell, 6 Richie Vernon, 7 David Seymour, 8 Andy Powell.Replacements: 16 Marc Jones, 17 Vadim Cobilas, 18 Tony Buckley, 19 Kearnan Myall, 20 Mark Easter, 21 Cillian Willis, 22 Tasesa Lavea, 23 Tom Brady
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