Mark Cueto, Danny Cipriani, Kearnan Myall and Richie Vernon will make their first starts of the season following the disappointing opening-day rout against Exeter.
There is also a place for the fit-again Alasdair Dickinson on the bench, however Marc Jones, Cillian Willis and Andy Powell are ruled out through injury.
Saracens have named an unchanged starting XV following last weekend's 40-3 season opening victory over London Irish.
The only changes in McCall's 23-man squad come on the bench where Alistair Hargreaves and Owen Farrell have been named.
Both shaken off minor knocks to be included, with second-row Hargreaves set to make his Aviva Premiership debut should he take to the field.
The other change sees Jared Saunders named among the replacement props on the bench.
Sale: 15 Rob Miller, 14 Will Addison, 13 Johnny Leota, 12 Sam Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 Richie Vernon, 7 David Seymour (capt), 6 James Gaskell, 5 Kearnan Myall, 4 Richie Gray, 3 Vadim Cobilas, 2 Joe Ward, 1 Eifion Lewis-Roberts.Replacements: 16 Tommy Taylor, 17 Alasdair Dickinson, 18 Henry Thomas, 19 Fraser McKenzie, 20 Mark Easter, 21 Will Cliff, 22 Nick Macleod, 23 Corne Uys.
Saracens: 15 Alex Goode, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 Chris Wyles, 10 Charlie Hodgson, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 Steve Borthwick (capt), 3 Petrus du Plessis, 2 Schalk Brits, 1 Mako Vunipola. Replacements: 16 Jamie George, 17 Jared Saunders, 18 Carlos Nieto, 19 Alistair Hargreaves, 20 Jackson Wray, 21 Neil de Kock, 22 Owen Farrell, 23 James Short.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
