The list includes 2003 England World Cup winner Ben Cohen, number eight Sisa Koyamaibole, prop Jack Forster and back-row forward Kristian Ormsby.
Other departures, including fly-half Charlie Hodgson's move to Saracens, Chris Bell joining Wasps and Carl Fearns joining Bath, had previously been announced by their new clubs.
Off-the-field exits, meanwhile, include backs coach Byron Hayward and conditioner Peter Finch.
Sale, who finished third-bottom in the Premiership, have already made 12 new signings for next term, including Munster pair Tony Buckley and Sam Tuitupou.
"Such a wholesale change of players and coaching staff is necessary considering the performances of the club in the last two seasons," said Steve Diamond, Sale's executive director of sport.
"With a couple of exceptions, the club declined to make offers to the departing players and staff."
Sale chief executive Mick Hogan added: "There are still a number of signings and re-signings to be announced in the next fortnight.
"By the start of June, all players and coaches will be in place to start pre-season conditioning."
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