Leonardo Ghiraldini gets the nod ahead of Fabio Ongaro at hooker, while Alessandro Zanni is preferred to Paul Derbyshire in the back-row.
Ongaro drops out of the squad altogether, while Derbyshire is named on the bench.
There is no doubting the experience in the Azzurri line-up, though, with the team having racked up 677 Test appearances.
Italy: 15 A Masi, 14 T Benvenuti, 13 G Canale, 12 G Garcia, 11 M Bergamasco, 10 L Orquera, 9 F Semenzato, 1 A Lo Cicero, 2 L Ghiraldini, 3 M Castrogiovanni, 4 C del Fava, 5 C van Zyl, 6 A Zanni, 7 R Barbieri, 8 S Parisse (capt). Replacements: 16 T D'Apice, 17 L Cittadini, 18 M Bortolami, 19 P Derbyshire, 20 E Gori, 21 R Bocchino, 22 L McLean.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
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Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
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The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.