The Warriors marked their return to the top flight, having secured promotion from the Championship at the first attempt last term, with a 17-12 victory over Sale at Sixways last weekend.
Despite the win there are still plenty who expect Richard Hill's side to be facing a battle for survival come the end of the campaign, but Redpath says he would be "naive" to expect anything other than a full-blooded contest in their West Country derby.
"Most of the people saying those things are paid to have an opinion," he said. "Players, coaches etc. have too much respect for each other to talk about who will be top or bottom. They know how difficult it is.
"The last time Worcester played at Kingsholm, they played very well, as they did the previous time.
"It'd be naive to think that this would be an easy game. They've got virtually a full squad while we've got players away and injured but that's just life."
The Cherry and Whites were denied an opening win at Northampton by a late Ryan Lamb penalty last weekend.
That blow was tough to take after they had battled back from 23-13 down to lead, and Redpath wants to see his side close out the win this time round.
He said: "We're back at Kingsholm and the Gloucester crowd have been brilliant for us over the past few season. It's important now that we do ourselves justice, tidy up our execution, precision and discipline and hopefully go one better than last week."
Redpath has handed full debuts to scrum-half Nick Runciman, once of Worcester, and lock Tom Savage with Dave Lewis and Alex Brown out injured.
There are also two changes among the Warriors ranks with fly-half Joe Carlisle and hooker Chris Fortey given the chance to shine. Club captain Chris Pennell misses out with a hamstring problem so Tom Arscott takes his bench place, while Marcel Garvey makes his 100th Warriors start against his former club.
Hill has warned his side of the threat posed by Gloucester's dangerous back three of Olly Morgan, James Simpson-Daniel and Charlie Sharples.
"We know the approach we want to adopt and know we must not kick badly to the back three of Gloucester, if you do that you are in trouble," said Hill.
"Northampton were intelligent and kept the ball away from them and the likes of Simpson-Daniel, Sharples and Morgan were kept quiet. You don't want to be giving them ball on the front foot that they can counter.
"They are lethal off turnovers and have been for years. They have a fantastic back three and if you lose possession or kick loosely then you are in trouble."
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.