The inclusion of the 20-year-old winger, who impressed at the 2010 and 2011 Junior World Rugby Trophy, is one of nine changes made following the 53-17 thumping by Italy.
Valery Tsnobiladze and Alexander Khrokin will make their first RWC starts, while Sergey Popov joins them in the front-row.
Lock Denis Antonov and flanker Artem Fatakhov also come into the pack, with hooker and captain Vladislav Korshunov rested.
In the backs, scrum-half Alexander Yanyushkin, the stand-in skipper, and centre Sergey Trishin join Simplikevich in the starting XV, with Vasily Artemyev switching to full-back.
Russia: 15 Vasily Artemyev, 14 Denis Simplikevich, 13 Andrey Kuzin, 12 Sergey Trishin, 11 Vladimir Ostroushko, 10 Konstantin Rachkov, 9 Alexander Yanyushkin (captain), 8 Victor Gresev, 7 Andrey Garbuzov, 6 Artem Fatakhov, 5 Adam Byrnes, 4 Denis Antonov, 3 Alexander Khrokin, 2 Valery Tsnobiladze, 1 Sergey Popov. Replacements: 16 Evgeny Matveev,17 Ivan Prishchepenko, 18 Alexey Travkin, 19 Alexander Voytov, 20 Andrey Bykanov, 21 Mikhail Sidorov, 22 Mikhail Babaev.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.