Leguizamon has overcome concerns over an ankle injury and will start as the Pumas look to secure their qualification for the quarter-finals.
Argentina will know exactly what they need to do against Georgia in order to progress into the last eight after group rivals England and Scotland meet the previous day.
The injury-hit Pumas set up their chance with a 13-12 victory over Scotland last weekend but have been left to count the cost, with inspirational number eight Juan Martin Fernandez Lobbe out for the tournament with a torn knee ligament.
Leonardo Senatore replaces Lobbe while Leicester prop Marcos Ayerza starts in the front row in place of Rodrigo Roncero, who is sidelined this weekend with a thigh strain.
Argentina coach Santiago Phelan has made one further change in the pack, with lock Mariano Galarza coming in for Manuel Carizza, and two in the backs.
Former Leicester flyer Lucas Amorosino, who scored the winning try against Scotland, is rewarded with a start at full-back while Juan Jose Imhoff comes onto the left wing.
Exeter's Gonzalo Camacho drops out of the 22-man squad and Martin Rodriguez moves to the bench.
Team: L Amorosino; H Agulla, M Bosch, F Contepomi (capt), J Imhoff; S Fernandez, N Vergallo; M Ayerza, M Ledesma, J Figallo, M Galarza, P Albacete, JF Cabello, JM Leguizamon, L Senatore.
Replacements: A Creevy, M Scelzo, T Vallejos, A Campos, A Lalanne, A Gosio, M Rodriguez
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