All of the Warrriors' squad are English qualified as hooker Chris Forte comes in for his 150th appearance in a pack that also includes England U20 star Matt Kvesic.
The half-back responsibilities have been handed to the young pairing of Joe Carlisle and Ollie Frost, while Chris Pennell is back to captain the side from centre.
Wasps have also used the clash to hand run-outs to some of their rising stars; Junior World Cup finalists Elliot Daly and Matt Everard among them.
Head coach Dai Young has utilised the dual-registration of Mike Powell, Ben Russell and Joe Ajuwa (London Welsh) and Karl Rudzki (London Scottish) and named all in the squad.
Exciting wings Charlie Ingall and Alex Cheesman earn their first starts for the club, and Jack Wallace gets the nod at full-back.
Worcester: Arscott, Short, Pennell (c), Crockett, Drauniniu, Carlisle, Frost; Porter, Fortey, Tomaszczyk, C Jones, Gillies, Betty, Kvesic, Balding.
Replacements: Hayes, Douglas, Currie, Gulliver, Muagututia, Gray, Goode, Penn.
Wasps: Wallace, Cheesman, Daly Mayor, Ingalis, Davis, Holmes; Castex, Lindsay, McIntyre, Filipo, Powell, Harris, Everard, Burton.
Replacements: Morris, Theide, Roan, Rudzki, Russell, C Davies, Robinson, Ajuwa.
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