Following the victory over London Irish, David Wilson, Francois Louw and Dan Hipkiss come into the Bath line-up.
Wilson joins Nathan Catt and Lee Mears, with Anthony Perenise named on the bench, while Louw gets the nod on the openside flank.
Former Leicester centre Hipkiss returns to partner Matt Carraro in the midfield.
Harlequins boss Conor O'Shea has made minimal changes to his side for the trip to the west country.
Joe Gray and Samoa flanker Maurie Fa'asavalu are handed starts for the clash, with Chris Brooker and Luke Wallace making way.
There is a return on the bench for England scrum-half Danny Care, with Nic Mayhew also included among the replacements.
Bath: 15 Nick Abendanon, 14 Olly Woodburn, 13 Dan Hipkiss, 12 Matt Carraro, 11 Tom Biggs, 10 Sam Vesty, 9 Michael Claassens, 1 Nathan Catt, 2 Lee Mears, 3 David Wilson, 4 Stuart Hooper (c), 5 Dave Attwood, 6 Ben Skirving, 7 Francois Louw, 8 Simon TaylorReplacements: 16 Ross Batty, 17 Charlie Beech, 18 Anthony Perenise, 19 Ryan Caldwell, 20 Guy Mercer, 21 Chris Cook, 22 Tom Heathcote, 23 Jack Cuthbert
Harlequins: 15 Mike Brown, 14 Seb Stegmann, 13 George Lowe, 12 Jordan Turner-Hall, 11 Sam Smith, 10 Nick Evans, 9 Karl Dickson, 8 Nick Easter, 7 Chris Robshaw, 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Jonston, 2 Joe Gray, 1 Joe MarlerReplacements: 16 Chris Brooker, 17 Nic Mayhew, 18 Kyle Sickler, 19 Tomas Vallejos, 20 Luke Wallace, 21 Danny Care, 22 Rory Clegg, 23 Matt Hopper.
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