Having suffered a disastrous home to defeat to Edinburgh in their opening fixture, Exiles coach Toby Booth has made six switches to his starting line-up.
An all new front row sees Clarke Dermody return to captain the side, with David Paice at hooker and Faan Rautenbach at tighthead.
Joe Ansbro replaces the suspended Shontayne Hape, while Declan Danaher and Richard Thorpe start in the back row.
Blues are forced into two changes from the side that scored a fantastic win over Racing Metro in Paris.
Injuries to Jamie Roberts and James Down sees Dafydd Hewitt come in at centre, with captain Paul Tito returning in the second row.
"We secured a great win out in Paris last weekend, but know it means nothing unless we back it up with a win against London Irish tomorrow," said Blues flanker Sam Warburton.
Cardiff Blues: Czekaj, Cuthbert, Laulala, Hewitt, James, Parks, Williams; Jenkins, Thomas, Filise, Davies, Tito, Paterson, Warburton, Rush.Replacements: Breeze, Yapp, Andrews, Molitika, Navidi, Rees, Sweeney, Evans.
London Irish: Homer, Ojo, Ansbro, Shingler, Thompstone, Bowden, Samson; Dermody, Pairce, Rautenbach, Kennedy, Garvey, Danaher, Thorpe, Sinclair.Replacements: Buckland, Corbisiero, Ion, Sandford, Gibson, Spratt, Jarvis, Hodgson.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.